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. Author manuscript; available in PMC: 2022 Apr 16.
Published in final edited form as: Neurochem Res. 2017 Apr 12;42(9):2551–2559. doi: 10.1007/s11064-017-2246-4

Figure 2.

Figure 2

NPPB increased tonic currents of dentate gyrus granule cells in acute hippocampal brain slices. A: Tonic currents under control conditions, during NPPB (100 μM) application, and after wash out of NPPB. All points histograms and Gaussian fits used to determine tonic current amplitudes [i.e. change in holding current produced by bicuculline (Bic)] are shown to right of each trace. Tonic current amplitudes are indicated by vertical lines. B: Time course for experiment in panel A. C: Tonic currents in presence of exogenous GABA (10 μM) before and during NPPB application. D: Mean tonic current amplitude under control conditions, in the presence of NPPB, exogenous GABA (GABA), and GABA + NPPB (n = 5 cells for NPPB alone, n = 3 cells with exogenous GABA). ** - p<0.01.

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