Table 2.
Analyses of the association of two SNPs with ankylosing spondylitis
| SNP | AS cases N (%) | Control N (%) | OR* | 95% CI | P-value |
|---|---|---|---|---|---|
| ERAP1 rs30187 | |||||
| C/C | 20 (34.4) | 23 (35.4) | 1.00 | (Reference) | |
| C/T | 28 (48.3) | 32 (49.2) | 2.09 | (0.13–1.73) | 0.262 |
| T/T | 10 (17.2) | 10 (15.4) | 1.60 | (0.18–2.09) | 0.444 |
| Dominant model | |||||
| C/C | 20 (34.4) | 23 (35.4) | 1.00 | (Reference) | |
| C/T + T/T | 48 (65.5) | 42 (64.6) | 1.31 | (0.63–2.72) | 0.461 |
| Recessive model | |||||
| C/C + C/T | 30 (82.7) | 55 (84.6) | 1.00 | (Reference) | |
| T/T | 10 (17.2) | 10 (15.4) | 1.83 | (0.68–4.89) | 0.223 |
| HWE | 0.836 | ||||
| ERAP1 rs27044 | |||||
| C/C | 23 (39.6) | 27 (41.5) | 1.00 | (Reference) | |
| C/G | 26 (44.8) | 29 (44.6) | 1.96 | (0.14–1.83) | 0.302 |
| G/G | 9 (15.5) | 9 (13.8) | 2.12 | (0.13–1.70) | 0.254 |
| Dominant model | |||||
| C/C | 23 (39.6) | 27 (41.5) | 1.00 | (Reference) | |
| C/G + G/G | 34 (60.3) | 38 (58.4) | 1.05 | (0.50–2.16) | 0.864 |
| Recessive model | |||||
| C/C + C/G | 49 (84.4) | 56 (86.1) | 1.00 | (Reference) | |
| G/G | 9 (15.5) | 9 (13.8) | 1.14 | (0.42–3.10) | 0.793 |
| HWE | 0.786 |
AS ankylosing spondylitis; ERAP1 endoplasmic reticulum aminopeptidase 1; OR odds ratio; CI confidence interval; SNP single nucleotide polymorphism; HWE Hardy–Weinberg equilibrium
*Adjusted for age and gender