Table 3.

Results of MDR analysis

	Number of the risk factors	Testing balanced accuracy	CVC	P-value*
1	B27	0.8381	9/10	0.0101
2	B27, smoke	0.8458	9/10	0.0107
3	B27, rs30187, rs27044	0.8509	10/10	0.0130
4	B27, smoke, rs30187, rs27044	0.8513a	10/10	0.0016
5	Smoke, rs30187, rs27044	0.3983	10/10	0.0210
6	Smoke, rs30187	0.4447	8/10	0.6773
7	Smoke	0.5456	7/10	0.7032

The model with the maximum testing balnced accuracy and maximum CVC was considered as the best model

MDR multifactor dimensionality reduction, CVC cross validation consistency

*P-values were based on 1000 permutations

^aThe best interaction model in MDR analysis