Table 3.
Characteristics of patients with prolonged QTc vs. no prolonged QTc at baseline or follow-up for females and males
| Female with QTc > 470 ms | Male with QTc > 450 ms | |||||
|---|---|---|---|---|---|---|
| Normal baseline and Prolonged follow-up Qtc N = 83 |
Normal baseline and follow-up QTc N = 348 |
P value | Normal baseline and Prolonged follow-up Qtc N = 26 |
Normal baseline and follow-up QTc N = 77 |
P value | |
| Age at first HCQ/CQ Rx | 64.7 (16.5) | 58.7 (16.9) | 0.004 | 62.5 (18.5) | 62.3 (16.4) | 0.95 |
| Race (%) | ||||||
| White | 66 (79.5) | 249 (71.6) | 0.09 | 20 (76.9) | 68 (88.3) | 0.58 |
| Black | 7 (8.4) | 48 (13.8) | 0 (0) | 3 (3.9) | ||
| Hispanic | 3 (3.6) | 9 (2.6) | 0 (0) | 1 (1.3) | ||
| Asian | 1 (1.2) | 13 (3.7) | 1 (3.9) | 1 (1.3) | ||
| Other | 6 (7.2) | 29 (8.3) | 5 (19.2) | 4 (5.2) | ||
| BMI (kg/m2) | 28.4 (6.7) | 28.7 (7.5) | 0.78 | 27.6 (7.3) | 27.6 (4.9) | 0.999 |
| MI (%) | 34 (41.0) | 75 (21.6) | 0.0003 | 13 (50.0) | 37 (48.1) | 0.86 |
| Stroke (%) | 9 (10.8) | 22 (6.3) | 0.15 | 3 (11.5) | 6 (7.8) | 0.56 |
| Hypothyroidism (%) | 20 (24.1) | 86 (24.7) | 0.91 | 3 (11.5) | 7 (9.1) | 0.72 |
| Insurance type (%) | ||||||
| Medicare | 51 (61.5) | 173 (49.7) | 0.05 | 16 (61.5) | 40 (52.0) | 0.33 |
| Medicaid | 1 (1.2) | 5 (1.4) | 1 (3.9) | 1 (1.3) | ||
| Private | 31 (37.4) | 169 (48.6) | 9 (34.6) | 36 (46.8) | ||
| Others | 0 (0) | 1 (0.3) | 0 (0) | 0 (0) | ||
| Indication for HCQ/CQ (%) | ||||||
| SLE | 18 (21.7) | 79 (22.7) | 0.84 | 5 (19.2) | 7 (9.1) | 0.16 |
| Cutaneous SLE | 5 (6.0) | 26 (7.5) | 0.65 | 2 (7.7) | 5 (6.5) | 0.83 |
| RA | 37 (44.6) | 127 (36.5) | 0.17 | 11 (42.3) | 26 (33.8) | 0.43 |
| Othera | 73 (88.0) | 291 (83.6) | 0.32 | 22 (84.6) | 56 (72.7) | 0.22 |
| Duration on HCQ in months (median, IQR) | 8.9 (4.2,12.0) | 11.7 (5.4,12.0) | 0.14 | 8.2 (3.8,12.0) | 10.0 (4.9,12.0) | 0.39 |
Bolded indicated P < 0.05
BMI body mass index, CQ chloroquine, HCQ hydroxychloroquine, IQR interquartile range, MI myocardial infarction, QTc prolonged QT interval, RA rheumatoid arthritis, Rx prescription, SD standard deviation, SLE systemic lupus erythematosus
aOther rheumatic diseases such as osteoarthritis (ICD10: M15-19, ICD9: 715), other joint disorder (ICD10: M20-M25; ICD9: 716, 719), other soft tissue disorders (M70-79; ICD9 721.9, 729, 726, 728, 727, 728.0–728.3, 728.6–728.0)