Table 4.

Treg subset panel of the patients.

Parameters	All (n = 40)	Mild (n = 27)	Severe (n = 13)	P
CD4+CD25+ T cells, median ± IQR (%)	16.43 ± 11.43	17.54 ± 15.93	15.68 ± 8.84	0.3166#
CD4+CD25+ T cells, median ± IQR (/μL)	40.09 ± 56.26	40.48 ± 97.95	32.56 ± 34.53	0.0386#
Total Treg, mean ± SD (%)	18.73 ± 1.31	15.26 ± 0.97	25.94 ± 2.56	<0.0001
Total Treg, median ± IQR (/μL)	7.25 ± 11.82	7.21 ± 12.37	7.73 ± 8.27	0.4933#
Helios+ Treg, mean ± SD (%)	53.77 ± 4.51	65.09 ± 4.43	30.25 ± 6.86	<0.0001
Helios+ Treg, median ± IQR (/μL)	3.51 ± 9.38	4.74 ± 9.93	1.07 ± 3.16	0.0127#
Helios− Treg, mean ± SD (%)	45.22 ± 4.53	33.57 ± 4.47	69.42 ± 6.58	<0.0001
Helios− Treg, median ± IQR (/μL)	2.78 ± 4.48	2.18 ± 2.64	4.73 ± 4.54	0.0308#
CD39+ Treg, mean ± SD (%)	32.01 ± 3.26	26.74 ± 3.58	42.95 ± 5.81	0.0177
CD39+ T cell, median ± IQR (/μL)	1.68 ± 3.88	1.32 ± 3.20	1.79 ± 3.81	0.4133#
CD39− Treg, mean ± SD (%)	66.61 ± 3.17	71.38 ± 3.48	56.69 ± 5.81	0.0278
CD39− Treg, median ± IQR (/μL)	5.40 ± 7.56	6.43 ± 9.44	3.09 ± 5.12	0.1130#
CD45RA+ Treg, median ± IQR (%)	13.98 ± 15.33	11.63 ± 8.09	27.27 ± 16.14	0.0028#
CD45RA+ Treg, median ± IQR (/μL)	1.33 ± 1.42	1.17 ± 1.13	1.50 ± 1.70	0.2094#
CD45RA− Treg, median ± IQR (%)	85.37 ± 15.35	88.37 ± 8.16	72.73 ± 15.81	0.0018#
CD45RA− Treg, median ± IQR (/μL)	5.55 ± 10.63	5.55 ± 10.93	5.33 ± 5.42	0.2639#

^#Tested by the Mann-Whitney U test; others were tested by the unpaired t-test; SD: standard deviation; IQR: interquartile range.