Table 7.
Risk factors of Treg subpopulations for progression by logistic regression.
| Variable | Univariate analysis | P | Multivariate analysis | P |
|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | |||
| CD4+CD25+ T cells (/μL) | 0.98 (0.95, 1.00) | 0.08 | ||
| Total Treg (%) | 1.24 (1.08, 1.43) | 0.003∗∗ | 1.24 (1.06, 1.45) | 0.009∗∗ |
| Helios+ Treg (%) | 0.95 (0.92, 0.98) | 0.0015∗∗ | ||
| Helios+ Treg (/μL) | 0.90 (0.79, 1.03) | 0.13 | ||
| Helios− Treg (%) | 1.06 (1.02, 1.09) | 0.0012∗∗ | 1.06 (1.01, 1.10) | 0.008∗∗ |
| Helios− Treg (/μL) | 1.01 (0.94, 1.09) | 0.77 | ||
| CD39+ Treg (%) | 1.04 (1.00, 1.09) | 0.03∗ | ||
| CD39− Treg (%) | 0.96 (0.92, 1.00) | 0.04∗ | ||
| CD45RA+ Treg (%) | 1.07 (1.00, 1.15) | 0.04∗ | ||
| CD45RA− Treg (%) | 0.93 (0.85, 0.99) | 0.03∗ |
OR: odds ratio; ∗<0.05, ∗∗<0.01, and ∗∗∗<0.001.