Table 1.
Pooled risk of fractures in meta-analyses of cohorts and case–control studies in PLWH
| Meta-analyses | Number of studies | Pooled risk | Any fractures | Fragility fractures | Hip fractures | Vertebral fractures | |||
|---|---|---|---|---|---|---|---|---|---|
| HIV-infected vs non-infected | HIV + HCV co-infected vs HIV mono-infected | HIV + HCV co-infected vs non-infected | HIV-infected vs non-infected | HIV + HCV co-infected vs HIV mono-infected | HIV-infected vs non-infected | HIV-infected vs non-infected | |||
| Shiau et al. [5] | 4/5 | IRR | 1.58 (1.25, 2.00) | – | – | 1.35 (1.10, 1.65) | – | – | – |
| Dong et al. [6] | 6/4/3 | IRR | – | 1.77 (1.44, 2.18) | 2.95 (2.17, 4.01) | – | 1.70 (1.18, 2.43) | – | – |
| O'Neill et al. [7] | 5/2 | RR | – | 1.57 (1.33, 1.86) | 2.46 (1.03, 3.88) | – | – | – | – |
| Ilha et al. [8] | 9 | OR | – | – | – | – | – | – | 2.30 (1.37, 3.85) |
| Pramukti et al. [9] |
7 6 |
OR IRR |
1.91 (1.14, 3.22) 1.50 (1.27, 1.78) |
– | – | – | – | – | – |
| Starup-Linde et al. [10] | 9/6/3 | RR | 1.53 (1.46, 1.61) | – | – | 1.51 (1.41, 1.63) | – | 4.05 (2.99, 5.49) | – |
| Chang et al. [11] | 17/13/6/6 | RR | 1.91 (1.46, 2.49) | – | – | 1.68 (1.40, 2.01) | – | 1.88 (0.99, 3.57) | 1.97 (1.22, 3.20) |
IRR incidence rate ratio, RR relative risk, OR odd ratio, HIV human immunodeficiency virus, HCV hepatitis C Virus, vs versus