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. 2022 Apr 16;12:6369. doi: 10.1038/s41598-022-10317-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Parasite stage-driven modulation of macrophage transcripts encoding functionally related proteins during L. donovani infection. (A) Heatmaps of selected transcripts differentially regulated only by amastigotes (left panel), promastigotes (middle panel) or both (right panel). Manually curated ontology groups are shown for stage-specific regulated transcripts (left and middle panels). Analyses were carried out on data generated from at least three biological replicates. *Targets selected for validation by RT-qPCR. (B) Relative mRNA amounts of Ccl5, Cd274, and Hmox1 (normalized to Actb) were measured by RT-qPCR. Data are presented as mean ± SD (biological replicates, n = 3). *p < 0.05 (for the indicated comparisons), ns non-significant.