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. 2022 Apr 16;12:6369. doi: 10.1038/s41598-022-10317-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IPA predicts parasite stage-specific modulation of transcriptional regulators in macrophages infected L. donovani. (A) Activation score (Z) of transcriptional regulators predicted to be involved in the changes of mRNA abundance in macrophages upon L. donovani AMA and PRO infection. *Common upstream regulators identified in PRO, AMA datasets by IPA. (B) Percentage distribution of upregulated mRNAs associated with upstream transcriptional regulators predicted to be activated in macrophages upon L. donovani AMA and PRO infection. Total number of genes regulated by each transcription factor are shown in brackets. Analyses were carried out on data generated from at least three biological replicates.