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. 2022 Apr 16;13(4):355. doi: 10.1038/s41419-022-04775-z

Fig. 3. Polarization and categories of macrophage.

Fig. 3

Macrophages can polarize into two main phenotypes, M1 and M2, when stimulated by different substances. M2 macrophages can be further divided into four subtypes (M2a, M2b, M2c and M2d) for their characteristic secretion and functions in certain environment.