Table 2.
Summary of re-biopsy result (n = 109).
| Diagnosis | n | (%) | T790M | n | (%) | The success rate of re-biopsy (%) | |
|---|---|---|---|---|---|---|---|
|
Histology specimens (n = 59) |
Adenocarcinoma | 53 | (89.8) | Positive | 32 | (54.2) | 81.3 |
| Negative | 16 | (27.1) | |||||
| No PCR results | 5 | (8.5) | |||||
| SCLC transformation | 2 | (3.4) | |||||
| Sarcomatoid transformation | 1 | (1.7) | |||||
| No malignant cells | 3 | (5.1) | |||||
|
Cytology specimens (n = 18) |
Adenocarcinoma/malignant cells | 14 | (77.8) | Positive | 1 | (5.6) | 66.7 |
| Negative | 11 | (61.1) | |||||
| No PCR results | 2 | (11.1) | |||||
| SCLC transformation | 1 | (5.6) | |||||
| No malignant cells | 3 | (16.6) | |||||
|
Plasma liquid biopsy (n = 32) |
Detection of any EGFR mutations | 14 | (43.8) | Positive | 8 | (25) | 43.8 |
| Negative | 6 | (18.8) | |||||
| No detection of EGFR mutations | 18 | (56.2) | |||||
|
Total (n = 109) |
Adenocarcinoma/malignant cells | 81 | (74.3) | Positive | 41 | (37.6) | 67.9 |
| Negative | 33 | (30.8) | |||||
| No PCR results | 7 | (6.4) | |||||
| Transformation | 4 | (3.7) | |||||
| No malignant cells | 24 | (22) | |||||
SCLC, small cell lung cancer; PCR, Polymerase chain reaction; EGFR, epidermal growth factor receptor.