Table 1.
The expression correlation of CDKN2A, CMTM8, ILK and immune markers
| Cell type | Gene markers | CDKN2A | CMTM8 | ILK | |||
|---|---|---|---|---|---|---|---|
| COR | P value | COR | P value | COR | P value | ||
| B cell | FCRL2 | − 0.008 | 8.77e−01 | − 0.052 | 7.69e−01 | 0.077 | 1.22e−01 |
| CD19 | 0.05 | 3.18e−01 | 0.042 | 3.98e−01 | 0.114 | 2.11e−02 | |
| MS4A1 | − 0.005 | 9.17e−01 | 0.009 | 8.64e−01 | 0.062 | 2.15e−01 | |
| CD22 | 0.117 | 1.84e−02 | − 0.07 | 1.61e−01 | 0.202 | 3.96e−05 | |
| CD70 | 0.17 | 5.88e−04 | − 0.159 | 1.27e−03 | 0.332 | 6.64e−12 | |
| CD8+ T Cells | CD8A | 0.095 | 5.49e−02 | − 0.204 | 3.49e−05 | 0.095 | 5.7e−02 |
| CD8B | 0.059 | 2.39e−01 | − 0.041 | 4.04e−01 | 0.121 | 1.45e−02 | |
| Neutrophils | FCGR3B | 0.105 | 3.44e−02 | 0.022 | 6.57e−01 | 0.317 | 5.99e−11 |
| CEACAM3 | 0.105 | 3.36e−01 | 0.151 | 2.3e−03 | 0.323 | 2.61e−11 | |
| SIGLEC5 | 0.178 | 3.25e−04 | − 0.124 | 1.26e−02 | 0.403 | 2.64e−17 | |
| FPR1 | 0.159 | 1.28e−03 | − 0.148 | 2.71e−03 | 0.417 | 1.75e−18 | |
| CSF3R | 0.13 | 8.59e−03 | − 0.134 | 6.95e−03 | 0.323 | 2.53e−11 | |
| S100A12 | 0.078 | 1.18e−01 | − 0.053 | 2.86e−01 | 0.184 | 2.00e−04 | |
| Macrophages (M1) | CD68 | 0.144 | 3.56e−03 | − 0.215 | 1.2e−05 | 0.301 | 5.81e−10 |
| PTGS2 | 0.058 | 2.41e−01 | − 0.164 | 9.26e−04 | 0.039 | 4.33e−01 | |
| IRF5 | 0.101 | 4.14e−02 | 0.032 | 5.20e−01 | 0.142 | 4.06e−03 | |
| NOS2 | − 0.028 | 5.75e−01 | − 0.105 | 3.52e−02 | − 0.104 | 3.64e−02 | |
| Macrophages (M2) | CCL2 | 0.179 | 2.79e−04 | − 0.130 | 8.55e−03 | 0.348 | 4.93e−13 |
| IL10 | 0.179 | 2.64e−04 | − 0.086 | 8.26e−02 | 0.304 | 4.11e−10 | |
| CD163 | 0.175 | 4.09e−04 | − 0.225 | 4.80e−06 | 0.326 | 1.77e−11 | |
| VSIG4 | 0.187 | 1.51e−04 | − 0.149 | 2.55e−03 | 0.442 | 7.92e−21 | |
| CSF1R | 0.155 | 1.78e−03 | − 0.163 | 9.69e−04 | 0.422 | 0.422 − 19 | |
| FCGR2A | 0.124 | 1.74e−02 | − 0.185 | 1.810 − 04 | 0.326 | 1.66e−11 | |
| Dendritic cells | CD209 | 0.084 | 9.15e−02 | − 0.068 | 1.73e−01 | 0.189 | 1.23e−04 |
| CLEC9A | 0.026 | 6.05e−01 | 0.023 | 6.41e−01 | 0.181 | 2.47e−04 | |
| NK cells | KIR3DL3 | − 0.115 | 2.02e−02 | − 0.061 | 2.19e−01 | 0.055 | 2.71e−01 |
| NCR1 | 0.026 | 6.07e−01 | − 0.206 | 3e−05 | 0.115 | 2.02e−02 | |
| KLRD1 | 0.085 | 8.8e−02 | − 0.264 | 6.48e−08 | 0.208 | 2.44e−05 | |
| Th1 cells | TBX21 | 0.028 | 5.79e−01 | − 0.185 | 1.71e−04 | 0.127 | 1.93e−02 |
| Th2 cells | GATA3 | 0.185 | 1.73e−04 | − 0.088 | 7.69e−02 | 0.267 | 4.69e−08 |
| Treg | FOXP3 | 0.128 | 9.96e−03 | − 0.15 | 2.48e−03 | 0.283 | 6.69e−09 |
| CCR8 | 0.059 | 2.36e−01 | − 0.215 | 1.21e−05 | 0.224 | 5.03e−06 | |
| Monocyte | C3AR1 | 0.147 | 2.93e−03 | − 0.168 | 6.76e−04 | 0.361 | 5.63e−14 |
| CD86 | 0.128 | 9.92e−03 | − 0.206 | 2.76e−05 | 0.321 | 3.3e−11 | |
| CSF1R | 0.155 | 1.78e−03 | − 0.163 | 9.69e−04 | 0.422 | 5.34e−19 | |
| CD14 | 0.207 | 2.66e−05 | − 0.2 | 5.09e−05 | 0.438 | 1.77e−20 | |