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. 2022 Apr 16;19:95. doi: 10.1186/s12974-022-02449-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In situ injection of PDGFB or PDGFD induces fibrosis in uninjured spinal cord. A–L Immunofluorescence staining of PDGFB (red) and PDGFRβ (green) in sagittal and coronal sections of the Control and PDGFB groups at 7 days after injection. M–X Immunofluorescence staining of PDGFD (red) and PDGFRβ (green) in sagittal and coronal sections of the Control and PDGFD groups at 7 days after injection. Y–D’ Immunofluorescence staining of PDGFRβ (green), fibronectin (red) and laminin (violet) in sagittal sections of the PDGFB and PDGFB + SU16f groups at 7 days after injection. E’–J’ Immunofluorescence staining of PDGFRβ (green), fibronectin (red) and laminin (violet) in sagittal sections of the PDGFD and PDGFD + SU16f groups at 7 days after injection. Arrowheads indicate the sites of in situ injection. Scale bars: 200 μm