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. 2022 Apr 16;19:95. doi: 10.1186/s12974-022-02449-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Intrathecal injection of SU16f breaks the scar boundary, inhibits the lesion and inflammation after SCI. A–H Immunofluorescence staining of GFAP (red) and PDGFRβ (green) in sagittal sections of the Control and SU16f groups at 28 dpi. The region of interest (ROI) represents the boxed region on the left and shows the fibrotic/astrocytic scar boundary. I–P Immunofluorescence staining of CD68 (red) and PDGFRβ (green) in sagittal sections of the Control and SU16f groups at 28 dpi. ROI represents boxed region in the left. Q–R Quantification of the percentage of GFAP⁻ area Q or CD68⁺ area R in the area of the spinal cord segment spanning the injured core at 28 dpi. Asterisks indicate the injured core. Scale bars: 200 μm in G and O and 20 μm in H and P. **P < 0.01 and ***P < 0.001 by Student’s t test, n = 5 animals per group