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. 2021 Feb 4;29(3-4):127–137. doi: 10.1038/s41434-021-00231-3

Fig. 1. Efficacy of NT-3 gene transfer in Cx32 KO mice on rotarod performance, tested at baseline and 6 months post-treatment.

Fig. 1

Statistically, there was no difference between baseline and endpoint for the NT-3 group (n = 11, p = 0.11), while there is a significant reduction in the UT group (n = 13, **p = 0.002), Wilcoxon Rank Sum test for paired data (a). The difference (or delta reduction) in rotarod test time (endpoint-baseline) by group showed that the UT group had a clinically and statistically larger reduction in rotarod test time than the NT-3 group (median reduction time of 14.75 vs 6.25 s, P = 0.026), Wilcoxon Rank Sum test for unpaired data (b). Rotarod performance test of 3 (n = 13, median, 53 s) and 9 months old (n = 10, median, 50.5 s) wild type mice did not show any significant difference. nsp > 0.05, unpaired t-test (c).