Table 1.
Genotype frequency & allele distribution and TLR7 mRNA expression in the studied groups:
| Variables | Cases (n = 150) No. (%) |
Controls (n = 135) No. (%) |
P value | OR (95% CI) |
|---|---|---|---|---|
| Age (mean ± SD) | 38.70 ± 9.60 | 38.68 ± 9.86 | 0.992† | – |
| Gender | ||||
| Male | 81 (54.0) | 80 (59.3) | 0.371 | – |
| Female | 69 (46.0) | 55 (40.7) | ||
| SNP rs3853839 genotyping | ||||
| GG | 58 (38.7)⁎ | 6 (4.4) | <0.001 | 19.86 (7.85; 50.22) |
| GC | 55 (36.7) | 53 (39.3) | 2.13 (1.24;3.68) | |
| CC | 37 (24.7) | 76 (56.3)⁎ | ||
| Allele | ||||
| G | 171 (57.0) | 65 (24.1) | <0.001 | 4.18 (2.91;6.00) |
| C | 129 (43.0) | 205 (75.9) | ||
| TLR7 mRNA expression (mean ± SD) | 2.44 ± 0.89 | 1.06 ± 0.46 | <0.001 | – |
| TLR7 mRNA expression | ||||
| GG | 3.33 ± 0.40 | 1.18 ± 0.43 | <0.001 | |
| GC | 2.23 ± 0.38 | 1.05 ± 0.47 | <0.001 | – |
| CC | 1.37 ± 0.57 | 1.05 ± 0.46 | 0.005 | |
⁎
Significantly higher than their corresponding in the other groups.
†
Significantly lower than their corresponding in the other groups.