Table 1.
Baseline characteristics and major outcomes for the vaccinated and unvaccinated cohorts, before and after propensity score matching. Only characteristics with an overall prevalence above 5% after matching are presented here; for additional baseline characteristics see appendix Table A1.
| Vaccinated (unmatched) | Unvaccinated (unmatched) | Vaccinated (matched) | Unvaccinated (matched) | |
|---|---|---|---|---|
| COHORT SIZE | 10,024 | 83,957 | 9479 | 9479 |
| DEMOGRAPHICS | ||||
| Age; mean (SD) | 57.0 (17.9) | 51.9 (23.1) | 56.5 (18.0) | 57.6 (20.6) |
| Sex; n (%) female | 5950 (59.4) | 48,968 (58.3) | 5676 (59.9) | 5761 (60.8) |
| Race; n (%) | ||||
| White | 7208 (71.9) | 57,310 (68.3) | 6783 (71.6) | 6873 (72.5) |
| Black or African American | 1584 (15.8) | 16,296 (19.4) | 1540 (16.2) | 1514 (16.0) |
| Unknown | 802 (8.0) | 7843 (9.3) | 783 (8.3) | 756 (8.0) |
| Ethnicity; n (%) | ||||
| Hispanic or Latino | 1097 (10.9) | 7539 (9.0) | 1015 (10.7) | 974 (10.3) |
| Not Hispanic of Latino | 7199 (71.8) | 63,015 (75.1) | 6780 (71.5) | 6793 (71.7) |
| Unknown | 1728 (17.2) | 13,403 (16.0) | 1684 (17.8) | 1712 (18.1) |
| COMORBIDITIES | ||||
| BMI; mean (SD) | 30.0 (7.4) | 29.7 (8.3) | 30.1 (7.4) | 30.2 (7.5) |
| Overweight and obesity; n (%) | 3175 (31.7) | 30,363 (36.2) | 3086 (32.6) | 3263 (34.4) |
| Blood pressure; mean (SD) | ||||
| Diastolic | 74.7 (11.5) | 73.0 (12.1) | 74.6 (11.5) | 73.1 (11.6) |
| Systolic | 127.6 (19.0) | 124.2 (19.6) | 127.5 (18.8) | 126.0 (19.4) |
| Hypertensive diseases; n (%) | 5227 (52.1) | 46,211 (55.0) | 5060 (53.4) | 5197 (54.8) |
| Diabetes mellitus; n (%) | ||||
| Type 2 diabetes mellitus | 2508 (25.0) | 24,073 (28.7) | 2426 (25.6) | 2551 (26.9) |
| Chronic lower respiratory diseases; n (%) | ||||
| Asthma | 1526 (15.2) | 17,665 (21.0) | 1502 (15.8) | 1491 (15.7) |
| Bronchitis, not specified as acute or chronic | 887 (8.8) | 10,121 (12.1) | 870 (9.2) | 867 (9.1) |
| Other chronic obstructive pulmonary disease | 884 (8.8) | 10,493 (12.5) | 871 (9.2) | 958 (10.1) |
| Nicotine dependence; n (%) | 929 (9.3) | 11,509 (13.7) | 917 (9.7) | 935 (9.9) |
| Psychiatric comorbidities; n (%) | ||||
| Anxiety disorders | 3187 (31.8) | 31,966 (38.1) | 3098 (32.7) | 3159 (33.3) |
| Substance misuse | 1351 (13.5) | 16,299 (19.4) | 1334 (14.1) | 1373 (14.5) |
| Mood disorders | 2453 (24.5) | 27,245 (32.5) | 2408 (25.4) | 2458 (25.9) |
| Heart disease; n (%) | ||||
| Ischemic heart diseases | 2074 (20.7) | 18,880 (22.5) | 2013 (21.2) | 2114 (22.3) |
| Other forms of heart disease | 3573 (35.6) | 34,359 (40.9) | 3485 (36.8) | 3607 (38.1) |
| Chronic kidney diseases; n (%) | ||||
| Chronic kidney disease (CKD) | 1501 (15.0) | 15,137 (18.0) | 1471 (15.5) | 1561 (16.5) |
| Hypertensive chronic kidney disease | 783 (7.8) | 8795 (10.5) | 761 (8.0) | 812 (8.6) |
| Chronic liver diseases; n (%) | ||||
| Fatty (change of) liver, not elsewhere classified | 727 (7.3) | 6530 (7.8) | 705 (7.4) | 730 (7.7) |
| Cerebral infarction; n (%) | 497 (5.0) | 5384 (6.4) | 487 (5.1) | 508 (5.4) |
| Neoplasms (any); n (%) | 4184 (41.7) | 34,046 (40.6) | 4038 (42.6) | 4208 (44.4) |
| Disorders involving the immune mechanism; n (%) | 810 (8.1) | 5844 (7.0) | 778 (8.2) | 771 (8.1) |