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. 2022 Apr 13;16:1107–1120. doi: 10.2147/DDDT.S346376

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© 2022 Liu et al.

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Hepatoprotective effect of suramin was associated with inhibiting EGFR-ERK1/2 signaling pathway. (A–D) The protein expression of P2Y2R, TNF-α and IL-1β in the liver. (E and F) The protein expression levels of EGFR, p-EGFR, ERK1/2 and p-ERK1/2 in the liver. ***P < 0.001 compared to control group. ^##P < 0.01, ^###P < 0.001 compared to Alcohol group.

Abbreviation: Suramin-H, high dosage group of suramin (20 mg/kg).