TABLE 4.
Selected DCD characteristics by era.
| Variable | Overall | Era 1 | Era 2 | Era 3 | P-value |
|---|---|---|---|---|---|
| Date Range | 5/1/05 to 4/30/20 | 5/1/05 to 4/30/10 | 5/1/10 to 4/30/15 | 5/1/15 to 4/30/20 | |
| Cohort Size | 728 | 73 | 127 | 528 | |
| Recipient Characteristics | |||||
| Age (y) | 61 (53, 66) | 56 (46, 62) | 60 (49.5, 64) | 62 (55, 67) | <0.01* |
| Male sex (%) | 451 (62%) | 48 (65.8%) | 81 (63.8%) | 322 (61%) | 0.66 |
| Diagnosis | <0.01* | ||||
| Cystic Fibrosis/Immunodeficiency | 76 (10.4%) | 12 (16.4%) | 17 (13.4%) | 47 (8.9%) | |
| Obstructive Lung disease | 232 (31.9%) | 35 (47.9%) | 33 (26%) | 164 (31.1%) | |
| Pulmonary Vascular disease | 26 (3.6%) | 3 (4.1%) | 3 (2.4%) | 20 (3.8%) | |
| Restrictive Lung disease | 394 (54.1%) | 23 (31.5%) | 74 (58.3%) | 297 (56.2%) | |
| Medical Condition | 0.13 | ||||
| Not Hospitalized | 562 (77.2%) | 61 (83.6%) | 89 (70.1%) | 412 (78%) | |
| Hospitalized | 65 (8.9%) | 6 (8.2%) | 17 (13.4%) | 42 (8%) | |
| In ICU | 101 (13.9%) | 6 (8.2%) | 21 (16.5%) | 74 (14%) | |
| Functional Status | <0.01* | ||||
| ADL With No Assistance | 154 (21.5%) | 36 (50.7%) | 18 (14.4%) | 100 (19.2%) | |
| ADL With Assistance | 301 (42%) | 24 (33.8%) | 62 (49.6%) | 215 (41.3%) | |
| Disabled/Hospitalized | 261 (36.5%) | 11 (15.5%) | 45 (36%) | 205 (39.4%) | |
| On Ventilator | 44 (6%) | 5 (6.8%) | 13 (10.2%) | 26 (4.9%) | 0.08 |
| LAS | 39.1 (34.2, 51.7) | 36 (33.2, 41.8) | 42.8 (35, 59.5) | 39.1 (34.3, 51.7) | <0.01* |
| PRA | 0 (0, 0) | 0 (0, 3) | 0 (0, 2.5) | 0 (0, 0) | <0.01* |
| Days on Waitlist | 49 (14, 175) | 138 (47, 368) | 54 (12.5, 198) | 44 (14, 138.5) | <0.01* |
| Previous ECMO/on ECMO | 50 (6.9%) | 4 (5.5%) | 11 (8.7%) | 35 (6.6%) | 0.64 |
| Donor Characteristics | |||||
| Age | 39 (28, 48) | 41 (29, 47) | 39 (26.5, 49) | 38 (28, 48) | 0.90 |
| Male sex (%) | 433 (59.5%) | 40 (54.8%) | 90 (70.9%) | 303 (57.4%) | 0.02* |
| Smoking History | 53 (7.4%) | 12 (16.4%) | 9 (7.1%) | 32 (6.1%) | <0.01* |
| Anoxia Cause of Brain Injury | 286 (39.3%) | 24 (32.9%) | 44 (34.6%) | 218 (41.3%) | <0.01* |
| Donor Pulmonary Infection | 436 (59.9%) | 23 (31.5%) | 70 (55.1%) | 343 (65%) | < 0.01* |
| PaO2/FiO2 Ratio | 416.1 ± 88.3 | 443.1 ± 84.2 | 416.5 ± 87.7 | 412.4 ± 88.6 | 0.03* |
| DCD Donor Lung Utilization (%)A | 3.3% | 1.3% | 2.2% | 5.0% | 0.05* |
| Percentage of organ donors that are DCDB | 15.1% (20,396/135,521) | 9.8% (3,883/39,755) | 13.9% (5,745/41,450) | 19.8% (10,768/54,316) | 0.04* |
| DCD Fraction of all Lung Transplants (%) | 2.6% | 1.1% | 1.5% | 4.2% | 0.04* |
| Operative Characteristics and Outcomes | |||||
| Single Lung Transplant | 168 (23.1%) | 18 (24.7%) | 46 (36.2%) | 104 (19.7%) | <0.01* |
| Centers with DCD Lung transplant (% of all Lung Transplant Centers) | 41 (51.3%) | 14 (21.2%) | 24 (33.8%) | 38 (54.3%) | |
| Center DCD Volume | 4 (2, 12) | 3 (1, 6.75) | 3 (1.75, 4.25) | 10 (3.25, 18) | <0.01* |
| Ischemia Time (hours) | 6.3 (5.1, 8.2) | 5.6 (4.6, 6.6) | 5.8 (4.7, 7.6) | 6.5 (5.3, 8.7) | <0.01* |
| Length of Stay (days) | 21 (14, 37) | 17 (12, 29) | 21 (14, 37) | 22 (14, 38) | 0.03* |
| Postop Dialysis | 81 (11.1%) | 8 (11%) | 14 (11%) | 59 (11.2%) | 0.99 |
Data displayed as mean ± standard deviation (SD) median (interquartile range) for parametric or non-parametric continuous variables respectively and number (percent of total) for categorical variables. BMI, body mass index; GFR, glomerular filtration rate; ICU, intensive care unit; ADL, activities of daily living; LAS, lung allocation score; PRA, percent reactive antibodies; ECMO, extracorporeal membrane oxygenation. * indicates p < 0.05. A “DCD Donor Lung Utilization (%)” calculated as fraction of DCD donors where a lung was procured and transplanted divided by all DCD donors regardless of which organ was donated. B “Percentage of all Organ Donors that are DCD” calculated as all DCD donors regardless of which organ was donated divided by all organ donors (DBD and DCD).