FIGURE 11.

Post-synaptic expression of mGlu3 in dendritic shafts in layers II/III and V of rat PL mPFC. (A,B) In both layers II/III and V (but shown here in layer II/III), mGlu3s are visualized on the plasma membranes of dendritic shafts, often on the patch of membrane facing a mitochondrion. It is possible that mGlu3s are regulating cAMP influences on mitochondria at this location, e.g., regulating cAMP drive on internal calcium release near these organelles. However, there are no apparent synapses evident near the mGlu3 labeling. (C) mGlu3 labeling can also be seen on microtubules in dendritic shafts in both layers (but shown here in layer V), where it may be trafficking within the dendrite. There is also a limited post-synaptic mGlu3 component associated with glutamatergic-like axodendritic synapses (bottom of image). Synapses are between black arrows. Green arrowheads point to mGlu3 immunoreactivity. Profiles are pseudocolored for clarity. ax, axon; den, dendrite; mit, mitochondrion. Scale bars: 200 nm.