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. 2022 Apr 4;10:816764. doi: 10.3389/fcell.2022.816764

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Copyright © 2022 Pramusita, Kitaura, Ohori, Noguchi, Marahleh, Nara, Kinjo, Ma, Kanou, Tanaka and Mizoguchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SSHTN mice showed significant elevation of bone resorption determined by micro-CT. (A) Micro-CT reconstruction of the trabecular region below the distal femur growth plate and the cortical region of femoral midshaft of normal control or SSHTN mice (n = 4). Scale bar = 2 mm. (B–G) Quantitative measurement of bone morphometric-related parameters; (B) trabecular bone volume fraction (BV/TV), (C) trabecular number (Tb.N), (D) trabecular separation (Tb.Sp), (E) trabecular thickness (Tb.Th), (F) trabecular bone surface (BS/BV), and (G) cortical thickness (Ct.Th) of normal control and SSHTN mice (n = 4).