Table 1.
TP53 co-mutation as a poor prognostic factor in EGFR-mutated NSCLC patients.
| Study | TP53-mut vs. TP53-wt | EGFR-TKI Predictor | |||
|---|---|---|---|---|---|
| mOS (months) | mPFS (months) | DCR | ORR | ||
| Canale 2017 (17) | N/A | N/A | 70% vs. 88% (P=0.019) |
N/A | YES |
| Hou 2019 (34) | 28 vs. 52 (P=0.023) |
6.5 vs. 14 (P=0.025) |
76.7% vs. 89.3% (P=0.160) |
25 vs. 28% (P=0.374) |
YES |
| Christopoulos 2020 (35) | P<0.05 | P<0.001 | N/A | N/A | YES |
| Yu 2018 (37) | NR vs. 47 (P=0.036) |
N/A | N/A | N/A | YES |
| Cheng 2020 (38) | 21 vs. 40 (P=0.05) |
11.2 vs. 13.1 (P=0.2) |
N/A | N/A | YES (1st generation TKI) NO (2nd generation TKI) |
N/A, No Available.