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TP53 co-mutation is not associated with prognosis in EGFR-mutated NSCLC patients.
| Study | TP53-mut vs. TP53-wt | EGFR-TKI Predictor | ||
|---|---|---|---|---|
| mOS (months) | mPFS (months) | ORR | ||
| Rachiglio 2019 (23) | 18.9 vs. 23 (P = 0.19) |
12.3 vs. 9.9 (P = 0.29) |
N/A | N/A |
| Labbé 2017 (39) | 70.2 vs.71.2 (P = 0.39) |
10.0 vs. 16.8 (P = 0.06) |
54% vs. 66% (P = 0.42) |
YES |
N/A, No Available.
