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. 2022 Apr 4;9:858784. doi: 10.3389/fmed.2022.858784

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Copyright © 2022 Elsherif, Moreddu, Alam, Salih, Ahmed and Butt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Florescence-based smart contact lens for tear glucose sensing. (A) Photographs of the rabbit wearing the smart contact lens under ambient light illumination. (B) The rabbit eye wearing contact lens under illumination by UV LED light. (C) The worn lens in artificial tears containing glucose of 1 mM concentration. (D) The worn lens in artificial tears containing glucose of 5 mM concentration. (E) Blood glucose levels measured by a commercial glucose meter over time and their corresponding tear glucose levels measured by analyzing the fluorescent signals emitted from the contact lens worn on the rabbit eye. (F) The ratio of the blue and red channel (B/R) for the images taken for the contact lens worn in the rabbit eye and immersed in artificial tears with different glucose concentrations (67).