Table 1.
Down- and up- regulated miRNAs and their functional pathways in glioblastoma
| Tumor suppresser miRNAs | |||
|---|---|---|---|
| miR-125b | TNFAIP3,NKIRAS2 | TRAIL/NFkB Caspase signaling cascade | (1 20 ) |
| Micro RNA | Target | Functional pathway | Reference |
| miR-34a | CDK6, CCND1, NOTCH | Notch signaling pathway | ( 130 , 13 1) |
| miR-145 | BNIP3 | Notch signaling pathway | ( 133 ) |
| miRNA146-a | Notch1 | Notch signaling pathway | ( 129 ) |
| miR-7 | PI3K, Raf-1, FAK | Raf/MEK/ERK pathway | ( 29 , 30 ) |
| miR-449b-5p miR-410 miR-206 miR-562 |
c-MET | c-MET/AKT pathway | ( 34 , 35 , 37 , 38 ) |
| miR-554 | PARK7 | PI3K/AKT pathway | ( 46 ) |
| miR-579 miR-548 miR-4698 |
- | PI3K/AKT pathway | ( 60 , 61 ) |
| miR-6071 | ULBP2 | PI3K/AKT/mTOR | ( 62 ) |
| miR-489 | SPIN1 | PI3K/AKT/mTOR | ( 63 ) |
| miR-326 | PKM2 | PI3K/AKT/mTOR | ( 64 ) |
| miR-652 | FOXK1 | AKT/mTOR pathway | ( 65 ) |
| miR-153 | RICTOR | AKT/mTOR pathway | ( 66 ) |
| miR-128 | P70S6K1 | AKT/mTOR pathway | ( 67 ) |
| miR-145 | Oct4 and Sox2 | AKT/mTOR pathway | ( 68 ) |
| miR-32 | TSC1 | AKT/mTOR pathway | ( 76 ) |
| miR-124 | - | AKT/ STAT3 pathway | ( 86 ) |
| miR-16 miR-211 |
MMP-9 | PI3K/Akt/ NFkB pathway | ( 92 , 93 ) |
| miR-342 | BCL-x , MCL1 | AKT/NFkB/Bcl2 | ( 98 ) |
| miR-181 | Bcl2 | AKT/NFkB/Bcl2 | ( 78 ) |
| miR-32 | MDM2, TSC1 | AKT/ MDM2/p53 | ( 76 ) |
| miR-218 | IKKβ | PI3K/Akt/ NFkB pathway TRAIL/NFkB/ Caspase signaling cascade |
( 91 ) |
| Onco-miRNA | |||
| Micro RNA | Target | Functional pathway | Reference |
| miR-26a miR-1908 |
- | PI3K/AKT pathway | ( 43 , 44 ) |
| miR-23a | PTEN | PI3K/AKT pathway |
(
45
)
( 44 ) |
| AKT/NFkB pathway | |||
| miR-21 | Sox2, S6K, 4E-BP1 PDCD4 RECK |
AKT/mTOR pathway STAT3/β-catenin pathway AKT/ MDM2 pathway |
(
69
,
70
)
( 87 ) ( 105 ) |
| Tap63 LRRFIP1 |
Caspase signaling cascade TRAIL/ NFkB Caspase signaling cascade |
( 116 , 119 ) | |
| miR-503 miR-96 |
PDCD4 | AKT/mTOR | ( 74 , 75 ) |
| miR-30 | Caspase3 | Caspase signaling cascade | ( 116 ) |
| miR-184 | - | AKT/FOXO3 | ( 79 ) |
| miR-221 miR-222 |
P27kip-1 | AKT/FOXO3 | ( 80 ) |
| miR-10b | HomeoboxD10, Bim | AKT/FOXO3 | ( 82 , 83 ) |
| AKT/NFkB | ( 119 ) | ||
| miR-124-5p | NRP-1 | PI3K/Akt/ NFkB pathway | ( 90 ) |
| miR-127 | AKT/ NFkB/p53 | ( 104 ) | |
The table presents tumor suppressor and onco-miRNAs with observed effects upon their regulation in glioblastoma and the functional pathway impressing their direct targets.