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. 2022 Apr 4;10:857919. doi: 10.3389/fcell.2022.857919

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Copyright © 2022 Xu, Chen, Zhan, Marquez, Zhuo, Qi, Zhu, He, Chen, Zhang, Shen, Chen, Gu, Guo, Liu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role and mechanism of FABP5 in tumorigenesis and cancer development. FABP5 plays critical roles in cancer initiation and progression through the AKT pathway, NF-κB pathway, IL pathway, EGFR pathway, p53 pathway, and so on. AA: arachidonic acid; AEA: endocannabinoid anandamide; CRABP: cytosolic retinoic acid-binding protein; DPPC: dipalmitoyl phosphatidyl choline; EGFR: epidermal growth factor receptors; ERK: extracellular regulated protein kinases. FAAH: fatty acid amide hydrolase; FAS: fatty acids; FFA: free fatty acids; FABP5: fatty acid binding protein 5; GIP: glucose-dependent insulinotropic polypeptide; IFN: interferon; IL: interleukin; LCFAS: long-chain fatty acids; MMP: matrix metalloproteinase; NF-κB: nuclear factor-kappa B; NGF: nerve growth factor; PI3K: phophatidylinositol-3-kinase; PPAR: peroxisome proliferator-activated receptor; PPRE: proliferator-activated response element; RAR: retinoic acid receptor; ROS: reactive oxygen species; STAT: signal transducer and activator of transcription; Tc: cytotoxic T cell, CD8⁺ T cell; Th: helper T cell, CD4⁺ T cell; Treg: regulatory T cell; Tm: memory T cell.