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. 2022 Apr 4;13:868685. doi: 10.3389/fimmu.2022.868685

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Copyright © 2022 Xia, Wang and Xiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional prediction of Tenascin-C and its correlation with markers of epithelial-mesenchymal transition. (A) The protein-protein interaction network of Tenascin-C and its related genes was constructed from the Genemania database. (B) The functional annotation of Tenascin-C and its related genes was performed in three parts, namely cellular component (CC), molecular function (MF) and biological process (BP). (C) The keloid dataset (GSE145725) in the Gene Expression Omnibus (GEO) database was used to perform correlation analysis of Tenascin-C with epithelial markers (E-cadherin and zonula occludens-1) and mesenchymal markers (vimentin and fibronectin).