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. 2022 Apr 4;13:857727. doi: 10.3389/fimmu.2022.857727

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Copyright © 2022 Li, Teng, Jiang, Zhang, Luo, Liao and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SOCS3 suppresses inflammation in TP-infected macrophages via the JAK2-STAT3 pathway. (A, B) The concentrations of inflammatory cytokines (TNF-α and IL-1β) in the supernatants of THP-1 cells with or without TP infection following transfection with siNC or siSOCS3. (C, D) Western blot analysis of SOCS3, p-JAK2, JAK2, p-STAT3, and STAT3 in THP-1 cells transfected with siNC or siSOCS3. (E) Western blot analysis of SOCS3, p-JAK2, JAK2, p-STAT3, and STAT3 in piPSCs with or without YTHDF1 knockdown and transfected with control or SOCS3 plasmid. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.