Table 5.
Logistic regression analysis (univariate and multivariable analysis) for patients on second-line ART regimens
| Variable | VL suppression | LTFU | ||||||
| OR (95% CI) | P value | Adjusted OR (aOR) (95% CI) | P value | OR (95% CI) | P value | aOR (95% CI) | P value | |
| Current age (years) | ||||||||
| <25 | 1 | – | 1 | – | 1 | – | 1 | – |
| 25–34 | 1.72 (1.30 to 2.29) | <0.001 | 2.01 (1.40 to 2.89) | <0.001 | 1.57 (1.17 to 2.10) | 0.003 | 1.99 (1.36 to 2.91) | <0.001 |
| 35–49 | 2.73 (2.13 to 3.50) | <0.001 | 3.13 (2.26 to 4.32) | <0.001 | 1.30 (1.00 to 1.69) | 0.054 | 1.46 (1.03 to 2.08) | 0.034 |
| 50+ | 3.52 (2.63 to 4.70) | <0.001 | 3.91 (2.72 to 5.62) | <0.001 | 1.02 (0.76 to 1.36) | 0.888 | 1.09 (0.75 to 1.58) | 0.658 |
| Sex | ||||||||
| Female | 1 | – | 1 | – | 1 | – | 1 | – |
| Male | 0.90 (0.78 to 1.03) | 0.135 | 1.05 (0.89 to 1.23) | 0.568 | 0.87 (0.78 to 0.99) | 0.027 | 0.89 (0.78 to 1.01) | 0.077 |
| Most recent CD4 cell count | ||||||||
| ≤100 cells/µL | 1 | – | 1 | – | 1 | – | 1 | – |
| 101–200 cells/µL | 1.37 (1.10 to 1.70) | 0.004 | 1.28 (1.02 to 1.59) | 0.031 | 1.01 (0.82 to 1.24) | 0.923 | 0.95 (0.77 to 1.18) | 0.663 |
| 201–350 cells/µL | 2.27 (1.85 to 2.80) | <0.001 | 2.19 (1.77 to 2.71) | <0.001 | 0.78 (0.64 to 0.94) | 0.011 | 0.70 (0.57 to 0.85) | <0.001 |
| 351–500 cells/µL | 4.17 (3.27 to 5.33) | <0.001 | 4.13 (3.21 to 5.32) | <0.001 | 0.82 (0.67 to 1.01) | 0.059 | 0.70 (0.57 to 0.86) | 0.001 |
| >500 cells/µL | 8.23 (6.33 to 10.71) | <0.001 | 8.32 (6.33 to 10.93) | <0.001 | 0.53 (0.44 to 0.64) | <0.001 | 0.44 (0.36 to 0.54) | <0.001 |
| Years of ART initiation | ||||||||
| 2004–2010 (≤200 cells/µL period) | 1 | – | – | 1 | 1 | – | ||
| 2011–2014 (≤350 cells/µL period) | 0.89 (0.76 to 1.04) | 0.148 | 1.20 (1.01 to 1.44) | 0.040 | 0.90 (0.79 to 1.03) | 0.126 | 0.81 (0.70 to 0.93) | 0.004 |
| 2015 (≤500 cells/µL period) | 0.79 (0.58 to 1.07) | 0.127 | 1.21 (0.86 to 1.70) | 0.285 | 0.71 (0.54 to 0.95) | 0.019 | 0.62 (0.46 to 0.85) | 0.003 |
| 2016–2020 (universal test and treat period) | 0.73 (0.60 to 0.89) | 0.002 | 1.14 (0.90 to 1.44) | 0.284 | 0.52 (043 to 0.63) | <0.001 | 0.42 (0.33 to 0.52) | <0.001 |
| Level of care | ||||||||
| Hospital | 1 | 1 | 1 | |||||
| CHC | 1.18 (1.01 to 1.37) | <0.001 | 1.32 (1.11 to 1.57) | <0.001 | 0.88 (0.78 to 1.00) | 0.054 | 0.87 (0.69 to 1.08) | 0.206 |
| PHC | 0.67 (0.54 to 0.84) | <0.001 | 0.73 (0.57 to 0.94) | 0.014 | 0.80 (0.66 to 0.99) | 0.035 | 0.90 (0.78 to 1.04) | 0.153 |
Bold p values denote statistical significance at the p≤0.05 level.
ART, antiretroviral therapy; CHC, community health centre; LTFU, lost to follow-up; PHC, primary healthcare clinic; VL, viral load.