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GKT137831 alleviated DOX-induced mitochondrial damage both in vivo and in vitro. (A) Representative transmission electron microscopy image of cardiac mitochondrial ultrastructure. (B) Mitochondrial membrane potential measured with JC-1 staining (scale bar = 50 µm). CCCP was used as a positive control. DOX, doxorubicin; GKT, GKT137831; CCCP, carbonyl cyanide m-chlorophenylhydrazone.
