TABLE 1.
Basic clinical data for severe Candida infections with fluconazole therapya
| Parameter | No. (%) of patients | Mean duration (range) of therapy (days) | No. (%) cured |
|---|---|---|---|
| Total | 32 | ||
| Sex ratio (male/female) | 21/11 | ||
| Site of Candida infection (source of isolation) | |||
| Candidemia (blood) | 21 | 15.3 (7–28) | 15 (71.4) |
| Peritonitis, non-CAPD (ascites fluid) | 1 | 14 | 1 (100) |
| Peritonitis, CAPD (peritoneal dialysate) | 3 | 19 (15–25) | 2 (66.6) |
| Pyelonephritis (nephrostomy and catheterized urine) | 4 | 11.5 (8–14) | 4 (100) |
| Pyothorax (pleural effusion) | 1 | 10 | 1 (100) |
| Pneumonia (bronchoalveolar lavage fluid [bacterial count, >103/ml]) | 1 | 14 | 1 (100) |
| Definite infective endocarditis (blood) | 1 | 16 | 0 (0) |
| Coexisting bacterial infections | |||
| Severe pneumonia and respiratory failure | 11 | ||
| Pneumonia without respiratory failure | 5 | ||
| Septicemia | 4 | ||
| Peritonitis | 5 | ||
| Biliary tract infection | 3 | ||
| Pyelonephritis | 3 | ||
| Soft tissue infection | 1 | ||
| Pyothorax | 1 | ||
| Liver abscess | 1 | ||
| Total with coexisting bacterial infections | 24 (75) |
a
Age of patients (mean ± standard deviation), 60.8 ± 16.28 years; range, 16 to 85 years.