Table 7.

HMDB compound classification of differential metabolites of plasma between NCG group and CON group^a.

Super classb	Metabolitec	RT (s)d	m/ze	VIPf	p-valueg	Fold changeh
Alkaloids and derivatives	Cytochalasin B	278.052	480.276	2.343	0.015	0.171
Benzenoids	Hippuric acid	200.125	180.065	1.846	0.014	1.456
	4S,5S-antillatoxin A	436.075	504.343	2.310	0.001	1.390
	2,5-Dihydroxybenzoate	184.632	153.019	2.346	0.001	2.028
	Salicyluric acid	165.388	194.046	2.244	0.002	2.026
	3-Hhydroxybenzoate	155.842	137.024	2.192	0.002	1.623
	Catechol	148.222	109.029	1.647	0.039	1.390
Lipids and lipid-like molecules	PGF1 alpha	419.822	325.273	1.784	0.017	1.416
	PC (7:0/O-8:0)	393.329	482.323	1.453	0.047	1.257
	PE (18:0/0:0)	463.252	482.323	1.569	0.032	0.847
	PC (P-17:0/0:0)	461.479	494.359	1.893	0.030	0.841
	LysoPC [22:5(4Z,7Z,10Z,13Z,16Z)]	416.058	570.354	1.689	0.037	0.789
	LysoPE [0:0/22:5(4Z,7Z,10Z,13Z,16Z)]	410.399	528.307	2.193	0.002	0.722
	Epigallocatechin 3-O-caffeate	309.076	469.109	1.989	0.005	0.647
	Glycocholic acid	309.618	466.315	1.969	0.004	0.451
	Glycodeoxycholic acid	354.305	450.320	2.085	0.002	0.443
	Smenospongiarine	350.745	414.299	2.100	0.036	0.432
	Tetranor-PGFM	224.334	329.160	1.781	0.011	1.649
	Dodecanedioic acid	193.524	229.144	1.824	0.020	1.447
	Tetradecanedioic acid	227.044	257.176	1.941	0.008	1.367
	PE [18:1(9Z)/0:0]	426.305	478.293	1.730	0.025	1.196
	Phosphatidylcholine lyso 18:1	432.200	580.361	1.911	0.008	1.162
	14-methyl palmitic acid	518.448	269.248	1.531	0.036	0.848
	Stearic acid	546.263	283.264	1.892	0.005	0.804
	Eicosa-5Z,8Z-dienoic acid [20:2, n-12]	517.388	307.264	1.957	0.004	0.803
	Phosphatidylcholine lyso 20:4	404.111	602.346	1.969	0.006	0.781
	Arachidonic Acid	463.287	303.232	1.723	0.024	0.758
	16-hydroxy hexadecanoic acid	348.369	271.228	1.993	0.004	0.729
	7Z, 10Z, 13Z, 16Z, 19Z-docosapentaenoic acid	476.463	329.248	1.917	0.007	0.726
	Stearic acid ethyl ester	613.921	311.295	1.824	0.011	0.717
	cis-9,10-Epoxystearic acid	361.554	297.243	2.073	0.004	0.656
	Docosahexanoic acid	450.270	327.232	1.841	0.032	0.638
	Glycocholate	261.714	464.301	1.799	0.004	0.466
	Tauroursodeoxycholic acid	292.435	498.289	2.390	0.011	0.244
	Taurocholic acid	266.388	514.284	2.358	0.014	0.190
Organic acids and derivatives	Pyroglutamic acid	60.847	130.050	1.676	0.043	1.943
	N, N-Dimethylglycine	35.107	104.070	1.836	0.020	1.451
	L-Ornithine	27.910	133.097	1.515	0.031	0.765
	Sarcosine	34.145	88.040	1.876	0.010	1.136
	(R)-2-Hydroxystearic acid	415.344	299.259	1.731	0.022	0.794
Organic oxygen compounds	2,8-Dihydroxyquinoline-beta-D-glucuronide	188.995	338.086	1.766	0.029	1.631
	Pantothenic acid	158.242	220.117	1.623	0.036	0.756

^aCON, CON group, N = 6, basal diet without supplementation of N-carbamylglutamate; NCG, N = 8, treatment that added 20 (g/d·head) N-carbamylglutamate.

^bBased on the chemical structure of the metabolite in HMDB.

^cThe name of the substance that matches in the secondary mass spectrum.

^dRetention time.

^eMass-to-charge ratio.

^fariable Importance in the Projection value from OPLS–DA model.

^gp-Value: p-value from t-test.

^hThe quantitative ratio of the two experimental substances in the NCG group and the CON group.