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. 2022 Apr 4;13:838688. doi: 10.3389/fphar.2022.838688

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Copyright © 2022 Nie, Xiong, Lan, Song, Yu, Chen, Wang, Ren, Chen, Liu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sivelestat attenuates intestinal inflammation in HFHC-fed Apo E^-/- mice and NE-treated intestinal epithelial cells. (A–E) Male Apo E^-/- mice were fed with HFHC diet for 4 weeks and then treated with sivelestat (Siv, 50 mg/kg per day, intraperitoneal injection) or Veh for 8 weeks. ELISA analysis of intestinal protein levels of TNF-α (A), IL-1β (B), and MCP-1 (C). Immunoblot analysis of protein expressions of phosphorylated (phos-) IκB and IκB (D) and quantitative analysis of the relative density of phos-IκB/IκB (E). Data are shown as mean ± SEM. n = 6 mice/group, and **p < 0.01 and ***p < 0.001.