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. 2022 Apr 4;10:804247. doi: 10.3389/fcell.2022.804247

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Copyright © 2022 Wen, Li, Nie, Mao and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EV-transmitted circRNAs are involved in the progression of AS. CircRNAs are produced by back-splicing from mRNA and put into extracellular vesicles mainly exosomes and microvesicles, becoming EV-circRNAs. This process may be interfered by risk factors of antheroslerosis. After entering systemic circulation, theses EV-circRNAs are transported to recipient cells and regulating cells function in cytoplasm or nucleus. They may modulate the dysfunction of endothelial cells, phenotype switching of VSMCs, inflammatory response, lipid deposition, vascular calcification and the formation of form cells to participate in antherosclerosis pathogenesis. CircRNA: circular RNA; mRNA: messenger RNA; ECs: endotherlial cells; VSMCs: vascular smooth muscle cells; EndoT; Endothelial mesenchymal transition.