TABLE 1.

CircRNAs are involved in the development of AS risk factors.

Risk factor	CircRNA	Dysregulation	Function	Cell/Model	Ref
Dyslipedemia	CircRNA_0046367	Down	Prevent hepatoxicity of lipid peroxidation against hepatic steatosis	HepG2 cells	Guo et al. (2017a)
	CircRNA_0046366	Down	Facilitate the transcriptional activation of lipid metabolism-associated genes	HepG2 cells	Guo et al. (2018)
	CircRNA_021412	Down	Disturb the balance between catalytic separation and adipogenesis	HepG2 cells	Guo et al. (2017b)
	CircScd1	Down	Impede lipid droplet formation and triglyceride content	AML-12 cells	Li et al. (2019a)
	Circ_0057558	Up	Facillitate lipogenesis and TG secretion	Huh-7 and HepG2 cells	Chen et al. (2021)
	CircACC1	Up	Facilitate the stability and activity of AMPK	HCT116 and LO2 cells	Li et al. (2019b)
	CDR1AS	Down	Increase insulin content and secretion	MIN6 cells	Xu et al. (2015)
Diabetes	CircHIPK3	Down	Impair the proliferation and capacity of insulin secretion and survival	Human islets cells	Cao et al. (2018)
	CircWDR77	Up	Promote high glucose induced proliferation and migration	Human VSMCs	Chen et al. (2017)
	Circ_0068087	Up	Promote chronic inflammation and vascular EC dysfunction in HG condition	HUVECs	Cheng et al. (2019)
	CircANKRd36	Up	Promote inflammation and cell apoptosis in the pancreatic tissues	T2DM rat model	Fang et al. (2018a)
	CircPPM1F	Up	promote activation and facilitate injury in pancreatic islets	PBMCs	Zhang et al. (2020a)
	Hsa_circH19	Up	Alleviate adipogenic differentiation	Human ADSCs	Zhu et al. (2020a)
Obesity	CircARF3	Up	Alleviate mitophagy-mediated inflammation and adipose inflammation	preadipocyte	Zhang et al. (2019a)
	CircSAMD4A	Up	Promote the differentiation of preadipocytes and obesity	preadipocyte	Liu et al. (2020)
	CircNrxn2	Down	Alleviate e WAT browning	preadipocyte	Zhang et al. (2019b)
	CiRS-133	Up	Promote WAT browning	preadipocyte	Zhang et al. (2019c)
	Has_circ_0126991	Up	Unknown	—	Liu et al. (2019a)
Hypertension	Has_circ_0005870	Down	Unknown	—	Wu et al. (2017)
	Has_circ_0037911	Up	Chang the concentration of Scr	—	Bao et al. (2018)
	CircZNF609	Up	Inhibit endothelial cell migration, tube formation, and apoptosis	HUVECs	Liu et al. (2017)
	Has_circ_0014243	Up	Unknown	—	Zheng et al. (2019)
	Hsa_circ_0105015	Up	Inflammatory pathways	HUVECs	He et al. (2021)
	Hsa_circ_0039388	Up	Enhance viability and invasive properties	HASMCs	Yin et al. (2020)
	Hsa_circ_0038648	Up	Enhance viability and invasive properties	HASMCs	Yin et al. (2020)
	Has-circRNA9102-5	Up	Unknown	—	Zheng et al. (2020)
	CircNr1h4	Down	Involved in hypertensive kidney injury	Mouse kidney collecting duct cells	Lu et al. (2020)
	Hsa_circ_0037897	Up	Unknown	—	Tao et al. (2021)

TG, total cholesterol; AMPK, AMP-activated protein kinase; EC, endothelial cell; HG, high glucose; WAT, white adipose tissue; Scr, serum creatinine; VSMCs, vascular smooth muscle cells; T2DM, type 2 diabetes mellitus; PBMCs, peripheral blood mononuclear cells; ADSCs, adipose-derived stem cells; HUVECs, human vein endothelial cells; HASMCs, human aortic endothelial cells.