TABLE 2.
EV-circRNAs and their partners related to atherosclerosis.
| CircRNA | Source | Recipient cell | Downstream pathways | Biological functions | Ref |
|---|---|---|---|---|---|
| CircIARS | Plasma | HMVECs | miR-122/RhoA | Reduce the permeability of the endothelial monolayer | Li et al. (2018) |
| Circ_0003204 | Plasma | HUAECs | miR-370-3p/TGFβR2/Phosph-Smad3 | Inhibit the proliferation, migration and tubular formation | Drew et al. (1981) |
| cPWWP2A | pericytes | HRVECs | miR-579–Angiopoietin1/Occludin/SIRT1 | Affect the proliferation and migration of ECs and the formation of tubular structures | Wang et al. (2019a) |
| CircHIPK3 | CMs | CMVECs | miR-29a/IGF-1 | Inhibit the apoptosis of CMVECs and the production of ROS | Wen et al. (2021) |
| circRNA-0006896 | Serum | HUVECs | miR-1264-DNMT1 | Enhance proliferation and migration in HUVECs | Peng et al. (2021) |
| CircRNA-0077930 | HUVECs | VSMCs | miR-622/Kras | Induce the VSMCs senescence | Chen et al. (2015) |
| CircDLGAP4 | Plasma | Mouse brain ECs and MCs | miR-143/HECTD1 | Inhibit EndoMT | Yang et al. (2018) |
| miR-143/ERBB3/p-NFκB/MMP-2 | Promote growth and fibrosis of MCs | Aimes and Quigley, (1995) |
HMVECs, human microvascular endothelial cells; HRVECs, human retinal vascular endothelial cells; HUAECs, human atrial endothelial cells; CMs, cardiomyocytes; CMVECs, cardiac microvascular endothelial cells; HUVECs, human umbilical vein endothelial cells; MCs, mesangial cells; ROS, reactive oxygen species; EndoMT, endothelial-mesenchymal transition.