TABLE 5.

The effect of PPIS on control patients.

	Demetria
	n	PY	IR	cHR	(95% CI)	aHR	(95% CI)
PPIs, cDDDs
non-user	455	205113	2.22	1.00	(reference)	1.00	(reference)
≤ 28	86	37617	2.29	0.95	(0.76, 1.20)	0.70	(0.55, 0.88)**
>28	63	17254	3.65	1.60	(1.23, 2.09)***	1.04	(0.79, 1.35)
p for trend					0.009		<0.001
PPIs, cDDDs
non-user	455	205113	2.22	1.00	(reference)	1.00	(reference)
≤ 84	128	50914	2.51	1.06	(0.87, 1.29)	0.76	(0.62, 0.93)**
>84	21	3957	5.31	2.45	(1.58, 3.79)***	1.36	(0.87, 2.11)
p for trend					0.2247		<0.001

*p-value < 0.05; **: p-value < 0.01; ***: p-value < 0.001.

n, number of events; PY, person-years; IR, incidence rate (per 1,000 person-years);

cHR, crude hazard ratio; aHR, adjusted hazard ratio. cDDDs: average cumulative defined daily dose per follow up year.

^†: adjusted by sex, age visit frequency and all comorbidities.