TABLE 6.

The effect of PPIS on GERD patients.

	Dementia
	n	PY	IR	cHR	(95% CI)	aHR	(95% CI)
PPIs,cDDDs
<10	23	11660	1.97	1.00	(reference)	1.00	(reference)
10–28	29	17971	1.61	0.82	(0.47, 1.42)	0.89	(0.52, 1.55)
28–66	39	18790	2.08	1.08	(0.64, 1.81)	1.15	(0.68, 1.92)
>66	87	16677	5.22	2.84	(1.79, 4.50)***	2.54	(1.59, 4.06)***
p for trend					<0.001		<0.001
PPIs,cDDDs
<70	93	49573	1.88	1.00	(reference)	1.00	(reference)
71–160	44	10702	4.11	2.31	(1.61, 3.31)***	2.16	(1.5, 3.11)***
161–325	24	3471	6.91	4.01	(2.56, 6.29)***	3.08	(1.94, 4.88)***
>325	17	1353	12.57	7.33	(4.36, 12.31)***	3.93	(2.32, 6.68)***
p for trend					<0.001		<0.001

*: p-value < 0.05; **: p-value < 0.01; ***: p-value < 0.001.

n, number of events; PY, person-years; IR, incidence rate (per 1,000 person-years);

cHR, crude hazard ratio; aHR, adjusted hazard ratio. cDDDs: average cumulative defined daily dose per follow up year.

^†: adjusted by sex, age, visit frequency and all comorbidities.