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. 2022 Apr 4;13:841149. doi: 10.3389/fphys.2022.841149

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Copyright © 2022 Guo, Liu, He, Yao and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein–protein interaction (PPI) network and hub gene analysis of DEGs in the fetal duodenum and jejunum. (A) PPI network interaction in the fetal duodenum. Interactions are indicated by edges, with thicker edges having stronger associations. MCODE cluster of PPI networks (B) and the top 10 hub genes (C) in the fetal duodenum. PPI network interaction (D), MCODE cluster of PPI networks (E), and the top 10 hub genes (F) in the fetal jejunum. The color of the node represents the clustering coefficient. The size of each node is proportional to the number of degrees. Interactions are indicated by edges, with thicker edges having stronger associations. Different colors represent the differing importance of the hub genes, in terms of their degree of connectivity. Higher ranks are represented by a deeper color.