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. 2022 Apr 8;19:139–154. doi: 10.1016/j.bioactmat.2022.03.042

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — MiR-146a-5p and miR-221-3p are enriched in hUCMSC-EVs. (A) Heat map of the top 10 most abundant miRNAs in hUCMSC-EVs by miRNA-seq. (B) Relative percentage of miRNAs in total miRNA reads. (C) Results of the RT-PCR analysis of the top five most abundant miRNAs in hUCMSCs and hUCMSC-EVs (n = 3). (D) Results of the RT-PCR analysis of the top five miRNAs in LF cells in the presence or absence of TGF-β1 and hUCMSC-EVs (n = 3). Data are presented as mean ± SD. *P < 0.05, **P < 0.01, compared with the control group. ^#P < 0.05, ^##P < 0.01, compared with the TGF-β1 group.