Figure 2.

SPMs direct cardiac repair and resolution of inflammation after cardiac injury. After ischemic cardiac insult to risk-free and healthy mice, splenic leukocytes orchestrate the biosynthesis of SPMs and facilitate cardiac repair. However, lifestyle-related diseases such as obesity, diabetes, and hypertension, dysregulate acute ‘physiological’ inflammation. After a cardiac injury, if acute inflammation remains unresolved, that advances to chronic ‘pathological’ inflammation leading to progressive heart failure. SPMs entity coordinate resolution process leading to cardiac repair.