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. 2022 Mar 26;25(4):104167. doi: 10.1016/j.isci.2022.104167

Figure 2.

Figure 2

Fusion genes found for the first time in pediatric RCC and discovery of a new germline FH mutation

(A) A complex gene fusion involving 3 different genes: TFE3, ASPSCR1, and SNX8 in RCC751.

(B) Discovery of gene fusion CRK-PITPNA in papillary pediatric RCC (RCC1176), associated with the second highest CRK expression across all pRCC.

(C) Germline structural variant within the FH gene (RCC380): duplication and intrachromosomal fusion of exon 1-7 with exon 2-10 and “second hit” copy-neutral LOH of the wild-type FH allele resulting in the lowest FH gene expression compared with all other pRCCs.