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. 2022 Mar 26;25(4):104167. doi: 10.1016/j.isci.2022.104167

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Copy-number profiles of the pediatric RCC cohort

(A) Copy-number profiles of the papillary pediatric RCC (ppRCC, n = 10) and the MiT-family translocation pediatric RCC (MiT-pRCC, n = 9^#) shown as average CNA per group. ^#RCC4039 was excluded due to poor DNA quality. ppRCC displayed high CNA frequency affecting predominantly gains of chr. 2, 7, 12, 16, 17, and 20. MiT-pRCC showed mostly a low CNA frequency; a high CNA count was predominantly restricted to metastatic/progredient (=poor prognosis-) RCC in older patients including losses of 1p, 3p, chr.4 or 4q, 9p, chr.11 or 11q, chr.18 and, partially, gains of 17q.

(B) Two metastatic MiT-pRCC cases selected from 3a displayed higher CNA frequency including losses of 3p, 9p, and chr.11 or 11q.

(C) Copy-number profiles of the chromophobe-RCC (RCC1348), the ALK-rearrangement-associated RCC (RCC1429), the post-neuroblastoma RCC (RCC419), and a secondary-malignancy, histologically unclassified RCC (RCC1230), each presented as a single case (copy-number profile of RCC380 see Figure 2C).