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. 2022 Mar 26;25(4):104167. doi: 10.1016/j.isci.2022.104167

Figure 5.

Figure 5

Tumor immune microenvironment (TME) deconvolution and gene expression of immune-regulatory, checkpoint or immunosuppressive activity-related genes in pediatric RCC (pRCC; n = 18)

(A) Fraction of different immune cell populations in each pRCC case.

(B) Overview of immune cell composition (median value of each cell type) in all pRCC, MiT-pRCC, and papillary pRCC (ppRCC).

(C) Fractions of selected immune cell types in all pRCC, MiT-pRCC, and ppRCC; dendritic cell fraction was significantly different between MiT-pRCC and ppRCC, p = 0.026 (Welch two sample t test).

(D) Unsupervised hierarchical clustering based on gene expression profiles of 59 immune-regulatory, checkpoint or immunosuppression-associated genes (Samstein et al., 2020) in pRCC.

(E) Anti-tumoral cytolytic activity (CYTscore) in all pRCC, MiT-pRCC, and ppRCC.

(F) Gene expression of selected immune checkpoint genes in all pRCC, MiT-pRCC, and ppRCC; ∗PD1 (p < 0.001, Wald test), ∗PD-L1 (p < 0.001, Wald test), ∗CTLA4 (p = 0.01, Wald test), and ∗TIGIT (p = 0.002, Wald test) significantly different between MiT-pRCC and ppRCC.