Table 2. In Vivo Pharmacokinetic Data of 9 in Rats after Oral and Intravenous Administration (Mean ± SD, N = 4).
route/dose (mg/kg) | Tmax (h) | C0 (ng/mL) | Cmax (ng/mL) | AUC0–t (h*ng/mL) | AUC0–inf (h*ng/mL) | T1/2 (h) | CL (mL/min/kg) | Vss (L/kg) | F (%) |
---|---|---|---|---|---|---|---|---|---|
IV (2) | NA | 491.99 ± 81.89 | NA | 277.61 ± 20.02 | 310.92 ± 12.94 | 3.25 ± 1.03 | 107.34 ± 4.58 | 18.05 ± 6.62 | NA |
PO (10) | 0.83 ± 0.29 | NA | 184.91 ± 14.54 | 540.25 ± 132.15 | 644.45 ± 266.94 | 2.86 ± 1.88 | NA | NA | 38.92 ± 9.52 |