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. 2022 Mar 29;65(7):5449–5461. doi: 10.1021/acs.jmedchem.1c01842

Table 2. In Vivo Pharmacokinetic Data of 9 in Rats after Oral and Intravenous Administration (Mean ± SD, N = 4).

route/dose (mg/kg) Tmax (h) C0 (ng/mL) Cmax (ng/mL) AUC0–t (h*ng/mL) AUC0–inf (h*ng/mL) T1/2 (h) CL (mL/min/kg) Vss (L/kg) F (%)
IV (2) NA 491.99 ± 81.89 NA 277.61 ± 20.02 310.92 ± 12.94 3.25 ± 1.03 107.34 ± 4.58 18.05 ± 6.62 NA
PO (10) 0.83 ± 0.29 NA 184.91 ± 14.54 540.25 ± 132.15 644.45 ± 266.94 2.86 ± 1.88 NA NA 38.92 ± 9.52