Scheme 1. Synthesis of the Isothiocyanate Building Block 17.
Reagents and conditions: (a) n-BuLi, isobutylsulfonyl chloride, THF, −78 °C → R.T., 12 h; (b) HCl, dioxane/CH2Cl2, 0 °C → R.T., 24 h; (c) 1,1′-thiocarbonyldiimidazole, CH2Cl2, R.T., 16 h.
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