Table 1. siRNA Sequences, IC₅₀, and T_m Values^a.

^adU₁dU (in red) corresponds to the deoxyuridine-based modification with a single long alkyl chain (−C₁₈H₂₇); dU₂dU (in blue) corresponds to the deoxythymidine-based modification with two long alkyl chains (−OC₁₈H₂₇); dU₃dU (in purple) corresponds to the deoxythymidine-based modification with three long alkyl chains (−OC₁₈H₂₇) attached to an aromatic group; dUxdU (in brown) corresponds to the phenylethyl modification from our previous study.²² The top strand is the sense strand; the bottom strand is the antisense strand. The antisense strand is 5′-phosphorylated. IC₅₀ values were calculated from luciferase data in the absence of a transfection carrier. NA = not applicable.