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. 2022 Mar 10;13(4):593–598. doi: 10.1021/acsmedchemlett.1c00652

Scheme 3. Synthetic Route for Compounds 17–28.

Scheme 3

Reagents and conditions: (a) 1-Boc-piperizine or mono-Boc-1,4-diazepane, DCM, 2 h, 44%–63%; (b) CF3COOH, DCM, rt, 3 h, 92–94%; (c) acyl chloride, Et3N, DCM, 88–90%; (d) corresponding sulfonyl chloride, Et3N, DCM, 86–91%.