Table 4. Thermodynamic Solubility and Plasma Protein Binding of Compounds MsPBTZ169, 2, 8, and PBTZ169.
| compd | solubility (μg/mL) | PPB, % |
|---|---|---|
| MsPBTZ169 | 0.64 | 97.5 |
| 2 | 0.81 | 97.9 |
| 8 | 0.70 | 98.4 |
| PBTZ169 | <0.01 | >99.9% |
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