Table 5. Liver Microsomal Stability of Compounds MsPBTZ169, 2, 8, and PBTZ169.
compd | species | t1/2 (min) | Clint, (mL/min/kg) |
---|---|---|---|
MsPBTZ169 | HLM | 28.8 | 60.5 |
MLM | 42.1 | 129.2 | |
2 | HLM | 38.6 | 45.1 |
MLM | 59.0 | 92.4 | |
8 | HLM | 22.6 | 77.0 |
MLM | 33.5 | 163.0 | |
PBTZ169 | HLM | 62.1 | 28.1 |
MLM | 31.5 | 173.6 |