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. 2022 Mar 10;13(4):593–598. doi: 10.1021/acsmedchemlett.1c00652

Table 5. Liver Microsomal Stability of Compounds MsPBTZ169, 2, 8, and PBTZ169.

compd species t1/2 (min) Clint, (mL/min/kg)
MsPBTZ169 HLM 28.8 60.5
  MLM 42.1 129.2
2 HLM 38.6 45.1
  MLM 59.0 92.4
8 HLM 22.6 77.0
  MLM 33.5 163.0
PBTZ169 HLM 62.1 28.1
  MLM 31.5 173.6